Clinical trials in primary care: bridging the gap between evidence-based recommendations and clinical practice


  • Athina Tatsioni Research Unit for General Medicine and Primary Health Care, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece



Clinical trials, Clinical practice




Não há dados estatísticos.


Sung NS, Crowley Jr WF, Genel M, Salber P, Sandy L, Sherwood LM, et al. Central challenges facing the national clinical research enterprise. JAMA. 2003;289(10):1278-87.

Westfall JM, Mold J, Fagnan L. Practice-based research: ‘blue highways’ on the NIH roadmap. JAMA. 2007;297(4):403-6.

Institute of Medicine. Crossing the quality chasm: a new health system for the 21st century [Internet]. Washington: National Academies Press; 2001. Available from:

McGlynn EA, Asch SM, Adams J, Keesey J, Hicks J, DeCristofaro A, et al. The quality of health care delivered to adults in the United States. N Engl J Med. 2003;348(26):2635-45.

Chalmers I, Matthews R. What are the implications of optimism bias in clinical research? Lancet. 2006;367(9509):449-50.

Madon T, Hofman KJ, Kupfer L, Glass RI. Public health: implementation science. Science. 2007;318(5857):1728-9.

Missiou A, Lionis C, Evangelou E, Tatsioni A. Health outcomes in primary care: a 20-year evidence map of randomized controlled trials. Fam Pract. 2022 Jul 9:cmac067. Online ahead of print.

Salmi LR, Barsanti S, Bourgueil Y, Daponte A, Piznal E, Ménival S, et al. Interventions addressing health inequalities in European regions: the AIR project. Health Promot Int. 2017;32(3):430-41.

Batista R, Pottie K, Bouchard L, Ng E, Tanuseputro P, Tugwell P. Primary health care models addressing health equity for immigrants: a systematic scoping review. J Immigr Minor Health. 2018;20(1):214-30.

Jones T, Luth EA, Lin SY, Brody AA. Advance care planning, palliative care, and end-of-life care interventions for racial and ethnic underrepresented groups: a systematic review. J Pain Symptom Manage. 2021;62(3):e248-60.

Rising ML, Hassouneh DS, Lutz KF, Berry P, Lee CL. Hispanic hospice utilization: integrative review and meta-analysis. J Health Care Poor Underserved. 2019;30(2):468-94.

Barrett K, Chang YP. Behavioral interventions targeting chronic pain, depression, and substance use disorder in primary care. J Nurs Scholarsh. 2016;48(4):345-53.

Melvin CL, Jefferson MS, Rice LJ, Nemeth LS, Wessell AM, Nietert PJ, et al. A systematic review of lifestyle counseling for diverse patients in primary care. Prev Med. 2017;100:67-75.

World Health Organization. Role of primary care in the COVID-19 response [homepage]. Manila: WHO Regional Office for the Western Pacific; 2020 [cited 2022 Sep 26]. Available from:

Mitchell S, Maynard V, Lyons V, Jones N, Gardiner C. The role and response of primary healthcare services in the delivery of palliative care in epidemics and pandemics: a rapid review to inform practice and service delivery during the COVID-19 pandemic. Palliat Med. 2020;34(9):1182-92.

Tatsioni A, Siountri I, Tsamoulis D, Vafeidou K. Clinical trials during pandemic in primary care: low number and low validity after one-year experience. Eur J Gen Pract. 2021;27(1):274-6.

Neves AL, Burgers J. Digital technologies in primary care: implications for patient care and future research. Eur J Gen Pract. 2022;28(1):203-8.

International Conference on Primary Health Care, World Health Organization, United Nations Children’s Fund. Primary health care: report of the International Conference on Primary Health Care, Alma-Ata, USSR, 6-12 September 1978 [homepage]. Geneva: World Health Organization; 1978 [cited 2022 Sep 26]. Available from:

Institute of Medicine. Primary care: America’s health in a new era [Internet]. Washington: National Academies Press; 1996. Available from:

Papagiannopoulou E, Laiou E, Tatsi C, Dimakopoulos G, Ntzani EE, Siamopoulos K, et al. Generalizability of randomized controlled trials in primary health care: applying the PRECIS-2 tool on published protocols. J Eval Clin Pract. 2022 Sep 7. Online ahead of print.




Como Citar

Tatsioni, A. (2022). Clinical trials in primary care: bridging the gap between evidence-based recommendations and clinical practice. Revista Portuguesa De Medicina Geral E Familiar, 38(5), 433–4.

Artigos Similares

1 2 3 > >> 

Também poderá iniciar uma pesquisa avançada de similaridade para este artigo.